Fisher, Bradford Hill, and randomization

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Fisher and Bradford Hill: theory and pragmatism?

provided the theoretical underpinning for tests of statistical significance.1 Because of this, it is often assumed that Fisher must have played a key role in the evolution of randomized trials in medicine during the 1930s and 1940s. Randomization was adopted by Austin Bradford Hill for Medical Research Council (MRC) trials for a more pragmatic reason, however. Bradford Hill was aware that an al...

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Fisher and Bradford Hill: their personal impact.

When the time came for me to leave school, there was only one subject I wanted to study: mathematics. I decided, however, for reasons that have been described elsewhere1 to read medicine instead. It was, therefore, not surprising that, as a medical student, I sought ways in which mathematics could be used in medicine and it was not long before I discovered one, when I came across Fisher’s2 book...

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Austin Bradford Hill (1897-1991)

During the twentieth century, Austin Bradford Hill researched diseases and their causes in England and developed the Bradford Hill criteria, which comprise the minimal requirements that must be met for a causal relationship to be established between a factor and a disease. Hill also suggested that researchers should randomize clinical trials to evaluate the effects of a drug or treatment by mon...

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Fifty years ago: Lancelot Hogben reviews Bradford Hill. 1948.

Principles of Medical Statistics. By A. BRADFORD HILL, Fourth Edition: 1948. London: Lanicet. Pp. 252. (Price lOs. 6d.) The appearance of a new edition of Professor Bradford Hill's manual, after three reprints of the third during the war years, is at once an indication of its successful appeal to the audience for whom the author wrote it and of a growing interest in the use of statistical metho...

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Does Zika Virus Cause Microcephaly - Applying the Bradford Hill Viewpoints

INTRODUCTION Zika virus has been documented since 1952, but been associated with mild, self-limiting disease. Zika virus is classified as an arbovirus from a family of Flaviviridae and primarily spread by Aedes Aegypti mosquitos. However, in a large outbreak in Brazil in 2015, Zika virus has been associated with microcephaly. METHODS In this review we applied the Bradford-Hill viewpoints  to ...

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ژورنال

عنوان ژورنال: International Journal of Epidemiology

سال: 2003

ISSN: 1464-3685,0300-5771

DOI: 10.1093/ije/dyg286